|
rs1344706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Together, these results indicated that IQ may modulate the role of rs1344706 in the etiology of both schizophrenia and its cognitive impairments, and pointed to the necessity of considering general cognitive function as indexed by IQ in the future studies of genetic bases of schizophrenia.
|
22373944 |
2012 |
|
rs17070145
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In comparison to APOE ε4-ve individuals carrying the rs17070145-T allele, significantly faster rates of cognitive decline (global, p = 0.006; verbal episodic memory, p = 0.004), and hippocampal atrophy (p = 0.04) were observed in individuals who were APOE ε4 + ve and did not carry the rs17070145-T allele.
|
29391469 |
2018 |
|
rs17070145
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No increased risk of any type of late development, and cognitive impairment was associated with rs6439886 or rs17070145.
|
21643791 |
2012 |
|
rs80338903
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs7840202
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies multiple novel loci associated with disease progression in subjects with mild cognitive impairment.
|
22833209 |
2011 |
|
rs387906709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overexpression of Ubqln2 with a pathogenic mutation (P497H substitution) caused cognitive deficits and neuronal loss in transgenic rats at the age of 130 days.
|
25388785 |
2015 |
|
rs781587642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In TUBA4A, we detected a novel frameshift mutation (p.Arg64Glyfs*90) leading to a truncated protein in 1 FTD patient (1/459 of 0.22%) with family history of Parkinson's disease and cognitive impairment, and a novel missense mutation (p.Thr381Met) in 2 sibs with familial ALS and memory problems (1 index patient/429, 0.23%) in whom we previously identified a pathogenic Chromosome 9 open reading frame 72 repeat expansion mutation.
|
28069311 |
2017 |
|
rs111231532
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.
|
26252872 |
2015 |
|
rs1569151872
|
|
AA |
0.700 |
GeneticVariation |
CLINVAR |
Mutations in TSPEAR, Encoding a Regulator of Notch Signaling, Affect Tooth and Hair Follicle Morphogenesis.
|
27736875 |
2016 |
|
rs139455627
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
Mutations in TSPEAR, Encoding a Regulator of Notch Signaling, Affect Tooth and Hair Follicle Morphogenesis.
|
27736875 |
2016 |
|
rs145959269
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.
|
26252872 |
2015 |
|
rs147368169
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.
|
26252872 |
2015 |
|
rs200956582
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.
|
26252872 |
2015 |
|
rs75932628
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that the TREM2 R47H gene variant was associated with changes in cognitive decline in the large cohort of HD patients, whereas 2 of 3 TLR4 single nucleotide polymorphisms assessed were associated with changes in motor progression in this same group.
|
31724242 |
2020 |
|
rs6910730
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We provide evidence that an intronic variant, rs6910730(G) , in TREM1, is associated with an increased burden of neuritic plaques (p = 3.7 × 10(-4) ), diffuse plaques (p = 4.1 × 10(-3) ), and Aβ density (p = 2.6 × 10(-3) ) as well as an increased rate of cognitive decline (p = 5.3 × 10(-3) ).
|
25545807 |
2015 |
|
rs121912651
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs10524523
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To interrogate a poly-T variant (rs10524523, '523) in <i>TOMM40</i>, a gene adjacent to the <i>APOE</i> gene on chromosome 19, in older persons with <i>APOE</i> ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD).
|
28108637 |
2017 |
|
rs10524523
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The very long (VL) poly-T variant at rs10524523 ("523") of the TOMM40 gene may hasten the onset of late-onset Alzheimer's disease (LOAD) and induce more profound cognitive impairment compared with the short (S) poly-T variant.
|
25862420 |
2015 |
|
rs115881343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with cognitive decline among African-Americans (p = 0.005), but rs115881343 was not.
|
24468470 |
2014 |
|
rs157582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline.
|
31760383 |
2019 |
|
rs2075650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our prevalent case study comparing prevalent AD cases (n = 428) with participants with no cognitive impairment (n = 524) revealed a significant association of rs6656401 and rs3818361 (CR1), rs2075650 (TOMM40), rs7561528 (BIN1), and rs3865444 (CD33) with late-onset AD that were robust to adjustment with age and apolipoprotein E ε4 genotype.
|
24176626 |
2014 |
|
rs1554948
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kinase, non-receptor, 1, TNK1) according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients.
|
28631188 |
2018 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients.
|
27701469 |
2016 |
|
rs117605016
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Variations in the FRA10AC1 Fragile Site and 15q21 Are Associated with Cerebrospinal Fluid Aβ1-42 Level.
|
26252872 |
2015 |
|
rs1558027212
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|